Today, industrial regions are in general not perceived as thriving and attractive places for CCI. However, locating CCI companies systematically there allows the economic structure to diversify and new regional value chains to develop. Highly promising for regions with transforming industries is as well the dimension of (non-technological) innovation that CCI adds to the existing economic and R&D fabric. Respective challenges are for example: SME in the industrial sector are less used to cooperate with external partners for innovation / CCI usually come into play only at a late stage / public support is still focused on technological innovation. Here you find novel and experimental approaches to how to change that and attract, establish and promote CCI and CCI clusters in traditional industrial regions.